Mesoporous silica nanoparticles combining Au particles as glutathione and pH dual-sensitive nanocarriers for doxorubicin
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چکیده
منابع مشابه
Thiol-functionalized mesoporous silica as nanocarriers for anticancer drug delivery
The present study deals with the synthesis andfunctionalization of mesoporous silica nanoparticles as drug delivery platforms. SBA-15 nanorods with high surface area (1010 m2g-1) were functionalized by post grafting method using 3-mercaptopropyl trimethoxysilane (MPTS). The parent and thiol-functionalized SBA-15 nanorods were used as nanocarriers for an anticancer drug (gemcitabine). The charac...
متن کاملThiol-functionalized mesoporous silica as nanocarriers for anticancer drug delivery
The present study deals with the synthesis andfunctionalization of mesoporous silica nanoparticles as drug delivery platforms. SBA-15 nanorods with high surface area (1010 m2g-1) were functionalized by post grafting method using 3-mercaptopropyl trimethoxysilane (MPTS). The parent and thiol-functionalized SBA-15 nanorods were used as nanocarriers for an anticancer drug (gemcitabine). The charac...
متن کاملStudy of Mesoporous Silica Nanoparticles as Nanocarriers for Sustained Release of Curcumin
Curcumin (CUR) is a hydrophobic molecule and beneficial antioxidant with known anticancer property. The bioavailability of curcumin is low because of its hydrophobic structure. Mesoporous silica nanoparticles (MSN) loaded by CUR were used as nanocarriers for sustained release of CUR in four different media such as simulated gastric,intestinal, colon and body fluids (SGF, SIF, SCF, and SBF, ...
متن کاملSugar and pH dual-responsive snap-top nanocarriers based on mesoporous silica-coated Fe3O4 magnetic nanoparticles for cargo delivery.
A facile strategy to prepare snap-top magnetic nanocarriers has been developed where ultrasmall superparamagnetic Fe3O4 nanoparticles were used as the core with mesoporous silica as the shell followed by the covalent installation of a layer of β-cyclodextrins on the outer surfaces. The smart hybrid nanomaterials showed remarkable pH- and sugar-responsive cargo release property and low cytotoxic...
متن کاملRedox-responsive mesoporous silica nanoparticles: a physiologically sensitive codelivery vehicle for siRNA and doxorubicin.
AIMS Efficient siRNA/drug codelivery carriers can offer great promises to cancer treatment on account of synergistic effect provided from cancer-associated gene and anticancer drugs. In this work, a redox-responsive drug/siRNA codelivery vehicle based on mesoporous silica nanoparticles was fabricated to simultaneously deliver siRNA and doxorubicin (Dox) in vitro and in vivo. RESULTS The nanop...
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ژورنال
عنوان ژورنال: Materials Science and Engineering: C
سال: 2016
ISSN: 0928-4931
DOI: 10.1016/j.msec.2015.10.022